Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect

Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect

Osteoarthritis (OA) is a common articular ailment presented with cartilage loss and destruction that is common observed in the elderly population. Physalin A (PA), a natural bioactive withanolide, exerts anti-inflammatory residences in more than a few diseases; however, little is known about its eff...

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Bibliographic Details
Main Authors: Rui Lu, Xiaojun Yu, Shuang Liang, Peng Cheng, Zhenggang Wang, Zhi-yi He, Zheng-tao Lv, Junlai Wan, Haokun Mo, Wen-tao Zhu, An-min Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Pharmacology
Subjects:
physalin A
osteoarthritis
αvβ3
integrin
MAPK
NF-κB
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.761922/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.761922/full

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