Myocardial overexpression of protein phosphatase 2A-B56α improves resistance against ischemia-reperfusion injury

Myocardial overexpression of protein phosphatase 2A-B56α improves resistance against ischemia-reperfusion injury

Protein phosphatase 2A (PP2A) plays a central role in myocardial ischemia-reperfusion (I/R) injury. Several studies showed a detrimental function of PP2A by using either overexpression models of the catalytic subunit (PP2Ac) or exogenous inhibitors of PP2Ac. However, all of these approaches underest...

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Bibliographic Details
Main Authors: Julius R. Herting, Anna M. Berg, Katarina Hadova, Alexander Heinick, Simone König, Michael Kuhlmann, Frank U. Müller, Uwe Kirchhefer
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Journal of Molecular and Cellular Cardiology Plus
Subjects:
Protein phosphatase 2A
Ischemia-reperfusion
Contractility
Protein phosphorylation
RISK signaling pathway
Acidosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2772976122000241

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http://www.sciencedirect.com/science/article/pii/S2772976122000241

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