Somatic Expression of PyMT or Activated ErbB2 Induces Estrogen-Independent Mammary Tumorigenesis

Somatic Expression of PyMT or Activated ErbB2 Induces Estrogen-Independent Mammary Tumorigenesis

Estrogen signaling is required for the proliferation of normal breast epithelial cells. However, prophylactic inhibition of estrogen signaling fails to prevent 56% of human breast cancer cases. The underlying mechanism is not well understood. Aberrant activation of growth factor signaling is known t...

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Bibliographic Details
Main Authors: Michael J. Toneff, Zhijun Du, Jie Dong, Jian Huang, Parisa Sinai, James Forman, Susan Hilsenbeck, Rachel Schiff, Shixia Huang, Yi Li
Format: Article
Language:English
Published: Elsevier 2010-09-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558610800739

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http://www.sciencedirect.com/science/article/pii/S1476558610800739

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