KAT2-mediated acetylation switches the mode of PALB2 chromatin association to safeguard genome integrity

KAT2-mediated acetylation switches the mode of PALB2 chromatin association to safeguard genome integrity

The tumour suppressor PALB2 stimulates RAD51-mediated homologous recombination (HR) repair of DNA damage, whilst its steady-state association with active genes protects these loci from replication stress. Here, we report that the lysine acetyltransferases 2A and 2B (KAT2A/2B, also called GCN5/PCAF),...

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Bibliographic Details
Main Authors: Marjorie Fournier, Amélie Rodrigue, Larissa Milano, Jean-Yves Bleuyard, Anthony M Couturier, Jacob Wall, Jessica Ellins, Svenja Hester, Stephen J Smerdon, László Tora, Jean-Yves Masson, Fumiko Esashi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-10-01
Series:eLife
Subjects:
PALB2
acetylation
chromatin
KAT2
DNA repair
genome stability
Online Access:https://elifesciences.org/articles/57736

Internet

https://elifesciences.org/articles/57736

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