High cell-free DNA is associated with disease progression, inflammasome activation and elevated levels of inflammasome-related cytokine IL-18 in patients with myelofibrosis

High cell-free DNA is associated with disease progression, inflammasome activation and elevated levels of inflammasome-related cytokine IL-18 in patients with myelofibrosis

Myelofibrosis (MF) is a clonal hematopoietic stem cell disorder classified among chronic myeloproliferative neoplasms, characterized by exacerbated myeloid and megakaryocytic proliferation and bone marrow fibrosis. It is induced by driver (JAK2/CALR/MPL) and high molecular risk mutations coupled to...

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Bibliographic Details
Main Authors: Geraldine De Luca, Paola R. Lev, Maria F. Camacho, Nora P. Goette, Federico Sackmann, Miguel A. Castro Ríos, Beatriz Moiraghi, Veronica Cortes Guerrieri, Georgina Bendek, Emiliano Carricondo, Alicia Enrico, Veronica Vallejo, Ana Varela, Marina Khoury, Marina Gutierrez, Irene B. Larripa, Rosana F. Marta, Ana C. Glembotsky, Paula G. Heller
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
myelofibrosis
inflammation
NLRP3 inflammasome
cell-free DNA
IL-18
AIM2 inflammasome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161832/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161832/full

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