Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.

Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.

Protein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory constraints on kinase activity, can promote malignant transformation, and appear to be a major determinant of respon...

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Bibliographic Details
Main Authors: Jeffrey C Lee, Igor Vivanco, Rameen Beroukhim, Julie H Y Huang, Whei L Feng, Ralph M DeBiasi, Koji Yoshimoto, Jennifer C King, Phioanh Nghiemphu, Yuki Yuza, Qing Xu, Heidi Greulich, Roman K Thomas, J Guillermo Paez, Timothy C Peck, David J Linhart, Karen A Glatt, Gad Getz, Robert Onofrio, Liuda Ziaugra, Ross L Levine, Stacey Gabriel, Tomohiro Kawaguchi, Keith O'Neill, Haumith Khan, Linda M Liau, Stanley F Nelson, P Nagesh Rao, Paul Mischel, Russell O Pieper, Tim Cloughesy, Daniel J Leahy, William R Sellers, Charles L Sawyers, Matthew Meyerson, Ingo K Mellinghoff
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-12-01
Series:PLoS Medicine
Online Access:http://europepmc.org/articles/PMC1702556?pdf=render

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http://europepmc.org/articles/PMC1702556?pdf=render

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