Neuronal FcεRIα directly mediates ocular itch via IgE-immune complex in a mouse model of allergic conjunctivitis

Neuronal FcεRIα directly mediates ocular itch via IgE-immune complex in a mouse model of allergic conjunctivitis

Abstract Background Classical understanding of allergic conjunctivitis (ACJ) suggests that ocular itch results from a mast cell-dependent inflammatory process. However, treatments that target inflammatory mediators or immune cells are often unsatisfying in relieving the stubborn itch symptom. This s...

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Bibliographic Details
Main Authors: Huan Cui, Fan Liu, Yehong Fang, Tao Wang, Bo Yuan, Chao Ma
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Journal of Neuroinflammation
Subjects:
Ocular itch
Allergic conjunctivitis
FcεRIα
Sensory neuron
Online Access:https://doi.org/10.1186/s12974-022-02417-x

Internet

https://doi.org/10.1186/s12974-022-02417-x

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