Targeting entry into mitochondria for increased anticancer efficacy of BCL-XL-selective inhibitors in lung cancer

Targeting entry into mitochondria for increased anticancer efficacy of BCL-XL-selective inhibitors in lung cancer

The BCL-XL-selective inhibitors exhibit potential clinical application value when combined with chemotherapeutic drugs for the treatment of solid tumors. However, their efficacy in these settings is still low when treated with BCL-XL inhibitors alone in solid tumors. The mechanism responsible for th...

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Bibliographic Details
Main Authors: Liangping Li, Pingping Li, Huanhuan Song, Xuesong Ma, Shulan Zeng, Yan Peng, Guohai Zhang
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Pharmacological Research
Subjects:
BCL-XL-selective inhibitor
Off-target
Improve
On-target
Synergistic therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661822000408

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http://www.sciencedirect.com/science/article/pii/S1043661822000408

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