Development and Validation of a New Mouse Model to Investigate the Role of SV2A in Epilepsy.

Development and Validation of a New Mouse Model to Investigate the Role of SV2A in Epilepsy.

SV2A is a glycoprotein present in the membranes of most synaptic vesicles. Although it has been highly conserved throughout evolution, its physiological role remains largely unknown. Nevertheless, Levetiracetam, a very effective anti-epileptic drug, has been recently demonstrated to bind to SV2A. At...

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Bibliographic Details
Main Authors: Catherine Menten-Dedoyart, Maria Elisa Serrano Navacerrada, Odile Bartholome, Judit Sánchez Gil, Virginie Neirinckx, Sabine Wislet, Guillaume Becker, Alain Plenevaux, Priscilla Van den Ackerveken, Bernard Rogister
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5115750?pdf=render

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http://europepmc.org/articles/PMC5115750?pdf=render

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