Investigating the potential anti-depressive mechanisms of statins: a transcriptomic and Mendelian randomization analysis

Abstract Observational studies and randomized controlled trials presented inconsistent findings on the effects of cholesterol-lowering statins on depression. It therefore remains unclear whether statins have any beneficial effects on depression, and if so, what the underlying molecular mechanisms ar...

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Bibliographic Details
Main Authors: Jiayue-Clara Jiang, Chenwen Hu, Andrew M. McIntosh, Sonia Shah
Format: Article
Language:English
Published: Nature Publishing Group 2023-04-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-023-02403-8