Acute administration of nicotine induces transient elevation of blood pressure and increases myocardial infarct size in rats

Aims: We investigated the acute effects of nicotine on myocardial infarct size, no reflow, hemodynamics and cardiac function in an acute myocardial ischemia and reperfusion infarction rat model. Main methods: Female Sprague-Dawley rats (n = 23/group) received an intravenous loading dose of nicotine...

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Bibliographic Details
Main Authors: Lifu Zhao, Wangde Dai, Juan Carreno, Jianru Shi, Michael T. Kleinman, Robert A. Kloner
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Heliyon
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020322933