The Redox Activity of Protein Disulfide Isomerase Inhibits ALS Phenotypes in Cellular and Zebrafish Models

The Redox Activity of Protein Disulfide Isomerase Inhibits ALS Phenotypes in Cellular and Zebrafish Models

Summary: Pathological forms of TAR DNA-binding protein 43 (TDP-43) are present in almost all cases of amyotrophic lateral sclerosis (ALS), and 20% of familial ALS cases are due to mutations in superoxide dismutase 1 (SOD1). Redox regulation is critical to maintain cellular homeostasis, although how...

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Bibliographic Details
Main Authors: Sonam Parakh, Sina Shadfar, Emma R. Perri, Audrey M.G. Ragagnin, Claudia V. Piattoni, Mariela B. Fogolín, Kristy C. Yuan, Hamideh Shahheydari, Emily K. Don, Collen J. Thomas, Yuning Hong, Marcelo A. Comini, Angela S. Laird, Damian M. Spencer, Julie D. Atkin
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:iScience
Subjects:
Neurogenetics
Molecular Biology
Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220302820

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http://www.sciencedirect.com/science/article/pii/S2589004220302820

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