Radiosensitization and a Less Aggressive Phenotype of Human Malignant Glioma Cells Expressing Isocitrate Dehydrogenase 1 (IDH1) Mutant Protein: Dissecting the Mechanisms

Radiosensitization and a Less Aggressive Phenotype of Human Malignant Glioma Cells Expressing Isocitrate Dehydrogenase 1 (IDH1) Mutant Protein: Dissecting the Mechanisms

The presence of an isocitrate dehydrogenase 1 (IDH1) mutation is associated with a less aggressive phenotype, increased sensitivity to radiation, and increased overall survival in patients with diffuse glioma. Based on in vitro experimentations in malignant glioma cell lines, the consequences on cel...

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Bibliographic Details
Main Authors: Jacqueline Kessler, Tim Hohmann, Antje Güttler, Marina Petrenko, Christian Ostheimer, Urszula Hohmann, Matthias Bache, Faramarz Dehghani, Dirk Vordermark
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cancers
Subjects:
isocitrate dehydrogenase 1
IDH1
IDH1<sup>R132H</sup>
glioma
glioblastoma
cell stiffness
atomic force microscopy
Online Access:https://www.mdpi.com/2072-6694/11/6/889

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https://www.mdpi.com/2072-6694/11/6/889

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