Hybrid Clustering of Single-Cell Gene Expression and Spatial Information via Integrated NMF and K-Means

Advances in single cell transcriptomics have allowed us to study the identity of single cells. This has led to the discovery of new cell types and high resolution tissue maps of them. Technologies that measure multiple modalities of such data add more detail, but they also complicate data integratio...

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Bibliographic Details
Main Authors: Sooyoun Oh, Haesun Park, Xiuwei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.763263/full