Early molecular events during retinoic acid induced differentiation of neuromesodermal progenitors

Early molecular events during retinoic acid induced differentiation of neuromesodermal progenitors

Bipotent neuromesodermal progenitors (NMPs) residing in the caudal epiblast drive coordinated body axis extension by generating both posterior neuroectoderm and presomitic mesoderm. Retinoic acid (RA) is required for body axis extension, however the early molecular response to RA signaling is poorly...

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Bibliographic Details
Main Authors: Thomas J. Cunningham, Alexandre Colas, Gregg Duester
Format: Article
Language:English
Published: The Company of Biologists 2016-12-01
Series:Biology Open
Subjects:
Embryonic stem cells
Neuromesodermal progenitors
Raldh2 knockout embryos
Retinoic acid target genes
Nkx1-2
Zfp503
Zfp703
Gbx2
Id1
Retinoic acid response elements
Online Access:http://bio.biologists.org/content/5/12/1821

Internet

http://bio.biologists.org/content/5/12/1821

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