Total Synthesis of Eliglustat via Diastereoselective Amination of Chiral <i>para</i>-Methoxycinnamyl Benzyl Ether

Total Synthesis of Eliglustat via Diastereoselective Amination of Chiral <i>para</i>-Methoxycinnamyl Benzyl Ether

Eliglustat (Cerdelga<sup>®</sup>, Genzyme Corp. Cambridge, MA, USA) is an approved drug for a non-neurological type of Gaucher disease. Herein, we describe the total synthesis of eliglustat <b>1</b> starting from readily available 1,4-benzodioxan-6-carbaldehyde via Sharpless...

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Bibliographic Details
Main Authors: Younggyu Kong, Pulla Reddy Boggu, Gi Min Park, Yeon Su Kim, Seong Hwan An, In Su Kim, Young Hoon Jung
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Molecules
Subjects:
amination
eliglustat
chlorosulfonyl isocyanate
Sharpless asymmetric dihydroxylation
total synthesis
Online Access:https://www.mdpi.com/1420-3049/27/8/2603

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https://www.mdpi.com/1420-3049/27/8/2603

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