Elongation factor 2 in cancer: a promising therapeutic target in protein translation

Abstract Aberrant elongation of proteins can lead to the activation of oncogenic signaling pathways, resulting in the dysregulation of oncogenic signaling pathways. Eukaryotic elongation factor 2 (eEF2) is an essential regulator of protein synthesis that precisely elongates nascent peptides in the p...

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Bibliographic Details
Main Authors: Xuechao Jia, Chuntian Huang, Fangfang Liu, Zigang Dong, Kangdong Liu
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cellular & Molecular Biology Letters
Subjects:
Online Access:https://doi.org/10.1186/s11658-024-00674-7