Design, synthesis, and apoptotic antiproliferative action of new 1,2,3-triazole/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors

Design, synthesis, and apoptotic antiproliferative action of new 1,2,3-triazole/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors

AbstractA novel series of 1,2,3-triazole/1,2,4-oxadiazole hybrids (7a–o) was developed as dual inhibitors of EGFR/VEGFR-2. Compounds 7a–o were evaluated as antiproliferative agents with Erlotinib as the reference drug. Results demonstrated that most of the tested compounds showed significant antipro...

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Bibliographic Details
Main Authors: Mohamed A. Mahmoud, Anber F. Mohammed, Ola I. A. Salem, Tahani Mazyad Almutairi, Stefan Bräse, Bahaa G. M. Youssif
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Triazole
oxadiazole
EGFR
VEGFR-2
apoptosis
antiproliferative
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2024.2305856

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2024.2305856

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