HPMA-Based Copolymers Carrying STAT3 Inhibitor Cucurbitacin-D as Stimulus-Sensitive Nanomedicines for Oncotherapy

HPMA-Based Copolymers Carrying STAT3 Inhibitor Cucurbitacin-D as Stimulus-Sensitive Nanomedicines for Oncotherapy

The study describes the synthesis, physicochemical properties, and biological evaluation of polymer therapeutics based on <i>N</i>-(2-hydroxypropyl)methacrylamide (HPMA) copolymers intended for a tumor-targeted immuno-oncotherapy. Water-soluble linear and cholesterol-containing HPMA prec...

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Bibliographic Details
Main Authors: Marina R. Tavares, Klára Hrabánková, Rafał Konefał, Martin Kaňa, Blanka Říhová, Tomáš Etrych, Milada Šírová, Petr Chytil
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Pharmaceutics
Subjects:
cucurbitacin-D
immuno-oncotherapy
<i>N</i>-(2-hydroxypropyl) methacrylamide (HPMA)
pH-controlled release
signal transducer and activator of transcription 3 (STAT3) inhibition
Online Access:https://www.mdpi.com/1999-4923/13/2/179

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https://www.mdpi.com/1999-4923/13/2/179

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