Co-culture with mouse embryonic fibroblasts improves maintenance of metabolic function of human small hepatocyte progenitor cells

Co-culture with mouse embryonic fibroblasts improves maintenance of metabolic function of human small hepatocyte progenitor cells

Derivation and culture of small hepatocyte progenitor cells (SHPCs) capable of proliferating in vitro has been described in rodents and recently in humans. These cells are capable of engrafting in injured livers, however, they display de-differentiated morphology and reduced xenobiotic metabolism ac...

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Bibliographic Details
Main Authors: Srikumar Sengupta, Brian Johnson, Morten Seirup, Hamisha Ardalani, Bret Duffin, Gregory A. Barrett-Wilt, Ron Stewart, James A. Thomson
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Current Research in Toxicology
Subjects:
Drug metabolism
Toxicity testing
Liver regeneration
Liver disease modeling
Hepatocyte transplantation
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X20300098

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http://www.sciencedirect.com/science/article/pii/S2666027X20300098

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