Neuroprotective effects of ulinastatin on Escherichia coli meningitis rats through inhibiting PKCα phosphorylation and reducing zonula occludens-1 degradation

Neuroprotective effects of ulinastatin on Escherichia coli meningitis rats through inhibiting PKCα phosphorylation and reducing zonula occludens-1 degradation

Abstract Ulinastatin, a broad-spectrum inflammatory inhibitor widely employed in the management of severe pancreatitis and sepsis, has not been extensively investigated for its therapeutic potential in bacterial meningitis. This study aims to assess the neuroprotective effects of ulinastatin on bact...

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Bibliographic Details
Main Authors: Xiaolan Zheng, Junsheng Wang, Huihong Su, Lingling Wu, Yan Zhang, Qianqian Tang, Tingting Ban, Kun Xie, Chunmiao Wei, Caimei Lin
Format: Article
Language:English
Published: Nature Portfolio 2024-09-01
Series:Scientific Reports
Subjects:
Blood–brain barrier
Bacterial meningitis
Zonula occludens-1
Protein kinase C
Escherichia coli
Online Access:https://doi.org/10.1038/s41598-024-72097-5

Internet

https://doi.org/10.1038/s41598-024-72097-5

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