Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer’s disease

Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer’s disease

Abstract Amyloid precursor protein (APP) metabolism is central to Alzheimer’s disease (AD) pathogenesis, but the key etiological driver remains elusive. Recent failures of clinical trials targeting amyloid-β (Aβ) peptides, the proteolytic fragments of amyloid precursor protein (APP) that are the mai...

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Bibliographic Details
Main Authors: Suman Rimal, Yu Li, Rasika Vartak, Ji Geng, Ishaq Tantray, Shuangxi Li, Sungun Huh, Hannes Vogel, Charles Glabe, Lea T. Grinberg, Salvatore Spina, William W. Seeley, Su Guo, Bingwei Lu
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Amyloid precursor protein C-terminal fragment (APP.C99)
Ribosome stalling
Ribosome-associated quality control
CAT-tailing
Proteostasis
Online Access:https://doi.org/10.1186/s40478-021-01268-6

Internet

https://doi.org/10.1186/s40478-021-01268-6

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