BCL9/9L-β-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer

BCL9/9L-β-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer

BCL9/9L proteins enhance the transcriptional output of the β-catenin/TCF transcriptional complex and contribute critically to upholding the high WNT signaling level required for stemness maintenance in the intestinal epithelium. Here we show that a BCL9/9L-dependent gene signature derived from indep...

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Bibliographic Details
Main Authors: Andreas E. Moor, Pascale Anderle, Claudio Cantù, Patrick Rodriguez, Norbert Wiedemann, Frédérique Baruthio, Jürgen Deka, Sylvie André, Tomas Valenta, Matthias B. Moor, Balázs Győrffy, David Barras, Mauro Delorenzi, Konrad Basler, Michel Aguet
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:EBioMedicine
Subjects:
WNT signaling
BCL9/9L-β-catenin
Cancer stem cells
Colorectal cancer subtypes
Patient outcome
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415301894

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http://www.sciencedirect.com/science/article/pii/S2352396415301894

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