WRN inhibits oxidative stress-induced apoptosis of human lensepithelial cells through ATM/p53 signaling pathway and its expression is downregulated by DNA methylation

WRN inhibits oxidative stress-induced apoptosis of human lensepithelial cells through ATM/p53 signaling pathway and its expression is downregulated by DNA methylation

Abstract Background Apoptosis and oxidative stress are the main etiology of age related cataract (ARC). This article aims to investigate the role of WRN in lens epithelial cells (LECs). Methods We estimated the methylation level of WRN in anterior lens capsule tissues of ARC patients. SRA01/04 (LECs...

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Bibliographic Details
Main Authors: Shengqun Jiang, Jiansu Chen
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Molecular Medicine
Subjects:
WRN
DNA methylation
Apoptosis
Oxidative stress
ATM/p53
Age related cataract
Online Access:http://link.springer.com/article/10.1186/s10020-020-00187-x

Internet

http://link.springer.com/article/10.1186/s10020-020-00187-x

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