Epilepsy-Induced High Affinity Blockade of the Cardiac Sodium Current I<sub>Na</sub> by Lamotrigine; A Potential for Acquired Arrythmias

Epilepsy-Induced High Affinity Blockade of the Cardiac Sodium Current I<sub>Na</sub> by Lamotrigine; A Potential for Acquired Arrythmias

Lamotrigine is widely prescribed to treat bipolar neurological disorder and epilepsy. It exerts its antiepileptic action by blocking voltage-gated sodium channels in neurons. Recently, the US Food and Drug Administration issued a warning on the use of Lamotrigine after observations of conduction ano...

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Bibliographic Details
Main Authors: Juan Antonio Contreras Vite, Carlos Vega Valle, Happi Biekeu Mbem, Sarah-Maude Boivin, Robert Dumaine
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Pharmaceuticals
Subjects:
ion channels
electrophysiology
patch clamp
Online Access:https://www.mdpi.com/1424-8247/15/10/1208

Internet

https://www.mdpi.com/1424-8247/15/10/1208

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