CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma

CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma

Abstract Background Glaucoma is a leading neurodegenerative disease affecting over 70 million individuals worldwide. Early pathological events of axonal degeneration and retinopathy in response to elevated intraocular pressure (IOP) are limited and not well-defined due to the lack of appropriate ani...

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Bibliographic Details
Main Authors: Prabhavathi Maddineni, Ramesh B. Kasetti, Pinkal D. Patel, J. Cameron Millar, Charles Kiehlbauch, Abbot F. Clark, Gulab S. Zode
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Molecular Neurodegeneration
Subjects:
Neurodegeneration
Ocular hypertension
Mouse model of glaucoma
Glucocorticoid-induced glaucoma
POAG
Retinal ganglion cell loss
Online Access:http://link.springer.com/article/10.1186/s13024-020-00400-9

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http://link.springer.com/article/10.1186/s13024-020-00400-9

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