Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe

Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe

Summary: Ancient genomics can directly detect human genetic adaptation to environmental cues. However, it remains unclear how pathogens have exerted selective pressures on human genome diversity across different epochs and affected present-day inflammatory disease risk. Here, we use an ancestry-awar...

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Bibliographic Details
Main Authors: Gaspard Kerner, Anna-Lena Neehus, Quentin Philippot, Jonathan Bohlen, Darawan Rinchai, Nacim Kerrouche, Anne Puel, Shen-Ying Zhang, Stéphanie Boisson-Dupuis, Laurent Abel, Jean-Laurent Casanova, Etienne Patin, Guillaume Laval, Lluis Quintana-Murci
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Cell Genomics
Subjects:
ancient DNA
immunity
host defense
natural selection
local adaptation
inflammatory disorders
Online Access:http://www.sciencedirect.com/science/article/pii/S2666979X22002117

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http://www.sciencedirect.com/science/article/pii/S2666979X22002117

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