Misincorporations of amino acids in p53 in human cells at artificially constructed termination codons in the presence of the aminoglycoside Gentamicin

Misincorporations of amino acids in p53 in human cells at artificially constructed termination codons in the presence of the aminoglycoside Gentamicin

Readthrough of a translation termination codon is regulated by ribosomal A site recognition and insertion of near-cognate tRNAs. Small molecules exist that mediate incorporation of amino acids at the stop codon and production of full-length, often functional protein but defining the actual amino aci...

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Bibliographic Details
Main Authors: Kamila Pawlicka, Tomas Henek, Lukas Uhrik, Lenka Hernychova, Monikaben Padariya, Jakub Faktor, Sławomir Makowiec, Borivoj Vojtesek, David Goodlett, Ted Hupp, Umesh Kalathiya
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Genetics
Subjects:
p53
stop codon
readthrough
gentamicin
NMD
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2024.1407375/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2024.1407375/full

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