Ablation of Fam20c causes amelogenesis imperfecta via inhibiting Smad dependent BMP signaling pathway

Ablation of Fam20c causes amelogenesis imperfecta via inhibiting Smad dependent BMP signaling pathway

Abstract Background Amelogenesis imperfecta (AI) is a type of hereditary diseases that manifest defects in the formation or mineralization of enamel. Recently, it is reported that inactivation of FAM20C, a well-known Golgi casein kinase, caused AI. However, the mechanism of it is still unknown. The...

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Bibliographic Details
Main Authors: Jing Liu, Wuliji Saiyin, Xiaohua Xie, Limin Mao, Lili Li
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Biology Direct
Subjects:
FAM20C
Amelogenesis Imperfecta
BMP signaling pathway
Ameloblast differentiation
Online Access:http://link.springer.com/article/10.1186/s13062-020-00270-7

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http://link.springer.com/article/10.1186/s13062-020-00270-7

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