Multiple treatments with human embryonic stem cell-derived mesenchymal progenitor cells preserved the fertility and ovarian function of perimenopausal mice undergoing natural aging

Multiple treatments with human embryonic stem cell-derived mesenchymal progenitor cells preserved the fertility and ovarian function of perimenopausal mice undergoing natural aging

Abstract Objectives Currently, no approved stem cell-based therapies for preserving ovarian function during aging. To solve this problem, we developed a long-term treatment for human embryonic stem cell-derived mesenchymal progenitor cells (hESC-MPCs). We investigated whether the cells retained thei...

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Bibliographic Details
Main Authors: Eun-Young Shin, Suji Jeong, Jeoung Eun Lee, Dong Seok Jeong, Dong Keun Han, Seok-Ho Hong, Dong Ryul Lee
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Stem Cell Research & Therapy
Subjects:
Human embryonic stem cell-derived mesenchymal progenitor cells (hESC-MPCs)
Ovarian function
Reproductive senescence
Fertility preservation of natural aging female
Myeloid-derived suppressor cells (MDSCs)
Online Access:https://doi.org/10.1186/s13287-024-03684-6

Internet

https://doi.org/10.1186/s13287-024-03684-6

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