Antihypertrophic Effects of Small Molecules that Maintain Mitochondrial ATP Levels Under Hypoxia

Antihypertrophic Effects of Small Molecules that Maintain Mitochondrial ATP Levels Under Hypoxia

Since impaired mitochondrial ATP production in cardiomyocytes is thought to lead to heart failure, a drug that protects mitochondria and improves ATP production under disease conditions would be an attractive treatment option. In this study, we identified small-molecule drugs, including the anti-par...

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Bibliographic Details
Main Authors: Hiroaki Nagai, Tomoko Satomi, Akiko Abiru, Kazumasa Miyamoto, Koji Nagasawa, Minoru Maruyama, Satoshi Yamamoto, Kuniko Kikuchi, Hiromitsu Fuse, Masakuni Noda, Yoshiyuki Tsujihata
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:EBioMedicine
Subjects:
Mitochondrial ATP
Cardiomyocytes
Hypertrophy
Hypoxia
Phenotypic screening
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417303766

Internet

http://www.sciencedirect.com/science/article/pii/S2352396417303766

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