Membrane anchored IL-18 linked to constitutively active TLR4 and CD40 improves human T cell antitumor capacities for adoptive cell therapy

Membrane anchored IL-18 linked to constitutively active TLR4 and CD40 improves human T cell antitumor capacities for adoptive cell therapy

Background Adoptive transfer of tumor-infiltrating lymphocytes (TILs) or blood T cells genetically redirected by an antitumor TCR or CAR induces a strong antitumor response in a proportion of patients with cancer; however, the therapeutic efficacy is often limited by rapid decline in T cell function...

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Bibliographic Details
Main Authors: Arpad Szoor, Gyorgy Vereb, Orit Itzhaki, Michal J Besser, Hinrich Abken, Dayana Blokon-Kogan, Maya Levi-Mann, Lior Malka-Levy, Yuval Shiftan, Gideon Gross, Hadas Weinstein-Marom
Format: Article
Language:English
Published: BMJ Publishing Group 2022-09-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/10/9/e001544.full

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https://jitc.bmj.com/content/10/9/e001544.full

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