3D inversion recovery ultrashort echo time MRI can detect demyelination in cuprizone-treated mice

3D inversion recovery ultrashort echo time MRI can detect demyelination in cuprizone-treated mice

PurposeTo test the ability of inversion-recovery ultrashort echo time (IR-UTE) MRI to directly detect demyelination in mice using a standard cuprizone mouse model.MethodsNon-aqueous myelin protons have ultrashort T2s and are “invisible” with conventional MRI sequences but can be detected with UTE se...

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Bibliographic Details
Main Authors: Adam C. Searleman, Yajun Ma, Srihari Sampath, Srinath Sampath, Robert Bussell, Eric Y. Chang, Lisa Deaton, Andrew M. Schumacher, Jiang Du
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Neuroimaging
Subjects:
MRI
IR-UTE
myelin imaging
mouse model
cuprizone
Online Access:https://www.frontiersin.org/articles/10.3389/fnimg.2024.1356713/full

Internet

https://www.frontiersin.org/articles/10.3389/fnimg.2024.1356713/full

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