Objective measurement and clinical significance of IDO1 protein in hormone receptor-positive breast cancer

Objective measurement and clinical significance of IDO1 protein in hormone receptor-positive breast cancer

Abstract Background Immunostimulatory therapies targeting immune-suppressive pathways produce durable responses in advanced solid tumors. Indoleamine 2,3-dioxygenase (IDO) is the rate-limiting oxidoreductase that catalyzes the degradation of tryptophan to kynurenine. IDO induces immune tolerance by...

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Bibliographic Details
Main Authors: Daniel E. Carvajal-Hausdorf, Nikita Mani, Vamsidhar Velcheti, Kurt A. Schalper, David L. Rimm
Format: Article
Language:English
Published: BMJ Publishing Group 2017-10-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
IDO1
Hormone receptor-positive
Survival
Tumor-infiltrating lymphocytes
Quantitative immunofluorescence
Online Access:http://link.springer.com/article/10.1186/s40425-017-0285-7

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http://link.springer.com/article/10.1186/s40425-017-0285-7

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