Huntington's disease phenotypes are improved via mTORC1 modulation by small molecule therapy.

Huntington's disease phenotypes are improved via mTORC1 modulation by small molecule therapy.

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Huntington's Disease (HD) is a dominantly inherited neurodegenerative disease for which the major causes of mortality are neurodegeneration-associated aspiration pneumonia followed by cardiac failure. mTORC1 pathway perturbations are present in HD models and human tissues. Amelioration of mTORC...

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Bibliographic Details
Main Authors: Sophie St-Cyr, Daniel D Child, Emilie Giaime, Alicia R Smith, Christine J Pascua, Seung Hahm, Eddine Saiah, Beverly L Davidson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0273710

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https://doi.org/10.1371/journal.pone.0273710

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