Species-Specific Differences in the Susceptibility of Fungi to the Antifungal Protein AFP Depend on C-3 Saturation of Glycosylceramides

Species-Specific Differences in the Susceptibility of Fungi to the Antifungal Protein AFP Depend on C-3 Saturation of Glycosylceramides

ABSTRACT AFP is an antimicrobial peptide (AMP) produced by the filamentous fungus Aspergillus giganteus and is a very potent inhibitor of fungal growth that does not affect the viability of bacteria, plant, or mammalian cells. It targets chitin synthesis and causes plasma membrane permeabilization i...

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Bibliographic Details
Main Authors: Norman Paege, Dirk Warnecke, Simone Zäuner, Silke Hagen, Ana Rodrigues, Birgit Baumann, Melanie Thiess, Sascha Jung, Vera Meyer
Format: Article
Language:English
Published: American Society for Microbiology 2019-12-01
Series:mSphere
Subjects:
antimicrobial peptide
antifungal protein AFP
gamma core
damage-response framework
sphingolipid
glycosylceramide
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00741-19

Internet

https://journals.asm.org/doi/10.1128/mSphere.00741-19

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