Increased Regulatory T-Cell Activity and Enhanced T-Cell Homeostatic Signaling in Slow Progressing HIV-infected Children

Increased Regulatory T-Cell Activity and Enhanced T-Cell Homeostatic Signaling in Slow Progressing HIV-infected Children

Pediatric slow progressors (PSP) are rare ART-naïve, HIV-infected children who maintain high CD4 T-cell counts and low immune activation despite persistently high viral loads. Using a well-defined cohort of PSP, we investigated the role of regulatory T-cells (TREG) and of IL-7 homeostatic signaling...

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Bibliographic Details
Main Authors: Julia Roider, Abigail Ngoepe, Maximilian Muenchhoff, Emily Adland, Andreas Groll, Thumbi Ndung'u, Henrik Kløverpris, Philip Goulder, Alasdair Leslie
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
pediatric HIV-infection
regulatory T cells (Treg)
immune activation (IA)
IL-7
homeostatic signaling
pediatric slow progression
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00213/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00213/full

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