Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children

Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children

Summary: Background: Protective malarial antibodies are acquired more rapidly in adults than children, independently of cumulative exposure, however the cellular responses mediating these differences are unknown. CD4 T-follicular helper (Tfh) cells have key roles in inducing antibodies, with Th2-Tf...

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Bibliographic Details
Main Authors: Damian. A. Oyong, Jessica. R. Loughland, Megan. S.F. Soon, Jo-Anne Chan, Dean Andrew, Bruce D. Wines, P. Mark Hogarth, Stuart D. Olver, Alika D. Collinge, Antiopi Varelias, James G. Beeson, Enny Kenangalem, Ric N. Price, Nicholas M. Anstey, Gabriela Minigo, Michelle J. Boyle
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:EBioMedicine
Subjects:
Plasmodium falciparum
T-follicular helper cells
immunity
malaria
antibodies
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421005788

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http://www.sciencedirect.com/science/article/pii/S2352396421005788

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