Olmesartan Prevents Microalbuminuria in db/db Diabetic Mice Through Inhibition of Angiotensin II/p38/SIRT1-Induced Podocyte Apoptosis

Olmesartan Prevents Microalbuminuria in db/db Diabetic Mice Through Inhibition of Angiotensin II/p38/SIRT1-Induced Podocyte Apoptosis

Background/Aims: Blockage of the renin-angiotensin II system (RAS) prevents or delays albuminuria in diabetic patients. The aim of this study was to investigate the inhibitory mechanism of the angiotensin receptor blocker olmesartan on albuminuria in a murine model of diabetic nephropathy. Methods:...

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Bibliographic Details
Main Authors: Junhui Gu, Ming Yang, Na Qi, Shuqin Mei, Jiejian Chen, Shuwei Song, Ying Jing, Meihan Chen, Liangliang He, Lijun Sun, Huimin Hu, Lin Li, Rudolf P. Wüthrich, Ming Wu, Changlin Mei
Format: Article
Language:English
Published: Karger Publishers 2016-11-01
Series:Kidney & Blood Pressure Research
Subjects:
Olmesartan
SIRT1
Podocytes
Apoptosis
Diabetic nephropathy
Online Access:http://www.karger.com/Article/FullText/452588

Internet

http://www.karger.com/Article/FullText/452588

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