Dexamethasone-associated metabolic effects in male mice are partially caused by depletion of endogenous corticosterone

Dexamethasone-associated metabolic effects in male mice are partially caused by depletion of endogenous corticosterone

Synthetic glucocorticoids are clinically used to treat auto-immune and inflammatory disease. Despite the high efficacy, glucocorticoid treatments causes side effects such as obesity and insulin resistance in many patients. Via their pharmacological target, the glucocorticoid receptor (GR), glucocort...

Full description

Bibliographic Details
Main Authors: Lisa L. Koorneef, Merel van der Meulen, Sander Kooijman, Elena Sánchez-López, Jari F. Scheerstra, Maaike C. Voorhoeve, Ajith N. Nadamuni Ramesh, Patrick C. N. Rensen, Martin Giera, Jan Kroon, Onno C. Meijer
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Endocrinology
Subjects:
Aldosterone
corticosterone
dexamethasone
eplerenone
glucocorticoid receptor
mineralocorticoid receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.960279/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.960279/full

Similar Items