Novel site-specific PEGylated L-asparaginase.

Novel site-specific PEGylated L-asparaginase.

L-asparaginase (ASNase) from Escherichia coli is currently used in some countries in its PEGylated form (ONCASPAR, pegaspargase) to treat acute lymphoblastic leukemia (ALL). PEGylation refers to the covalent attachment of poly(ethylene) glycol to the protein drug and it not only reduces the immune s...

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Bibliographic Details
Main Authors: Giovanna Pastore Meneguetti, João Henrique Picado Madalena Santos, Karin Mariana Torres Obreque, Christiano Marcello Vaz Barbosa, Gisele Monteiro, Sandra Helena Poliselli Farsky, Adriano Marim de Oliveira, Claudia Blanes Angeli, Giuseppe Palmisano, Sónia Patrícia Marques Ventura, Adalberto Pessoa-Junior, Carlota de Oliveira Rangel-Yagui
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0211951

Internet

https://doi.org/10.1371/journal.pone.0211951

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