Antitumour effect of the mitochondrial complex III inhibitor Atovaquone in combination with anti-PD-L1 therapy in mouse cancer models

Abstract Immune checkpoint blockade (ICB) provides effective and durable responses for several tumour types by unleashing an immune response directed against cancer cells. However, a substantial number of patients treated with ICB develop relapse or do not respond, which has been partly attributed t...

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Detalles Bibliográficos
Autores principales: Gonzalo Rodriguez-Berriguete, Rathi Puliyadi, Nicole Machado, Alessandro Barberis, Remko Prevo, Martin McLaughlin, Francesca M. Buffa, Kevin J. Harrington, Geoff S. Higgins
Formato: Artículo
Lenguaje:English
Publicado: Nature Publishing Group 2024-01-01
Colección:Cell Death and Disease
Acceso en línea:https://doi.org/10.1038/s41419-023-06405-8