A novel Drosophila model of TDP-43 proteinopathies: N-terminal sequences combined with the Q/N domain induce protein functional loss and locomotion defects

A novel Drosophila model of TDP-43 proteinopathies: N-terminal sequences combined with the Q/N domain induce protein functional loss and locomotion defects

Transactive response DNA-binding protein 43 kDa (TDP-43, also known as TBPH in Drosophila melanogaster and TARDBP in mammals) is the main protein component of the pathological inclusions observed in neurons of patients affected by different neurodegenerative disorders, including amyotrophic lateral...

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Bibliographic Details
Main Authors: Simona Langellotti, Valentina Romano, Giulia Romano, Raffaella Klima, Fabian Feiguin, Lucia Cragnaz, Maurizio Romano, Francisco E. Baralle
Format: Article
Language:English
Published: The Company of Biologists 2016-06-01
Series:Disease Models & Mechanisms
Subjects:
TDP-43
TBPH
Drosophila
ALS
FTLD
N-terminus
Aggregation
Online Access:http://dmm.biologists.org/content/9/6/659

Internet

http://dmm.biologists.org/content/9/6/659

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