Peptide-Based TNF-α-Binding Decoy Therapy Mitigates Lipopolysaccharide-Induced Liver Injury in Mice

Peptide-Based TNF-α-Binding Decoy Therapy Mitigates Lipopolysaccharide-Induced Liver Injury in Mice

A peptide named SEM18, possessing structural similarity to the binding site of tumor necrosis factor (TNF)-α to TNF receptor 1 (TNFR1), was designed. We investigated whether the SEM18 peptide can mitigate lipopolysaccharide (LPS)-induced liver injury in mice. Adult male Balb/cJ mice received LPS (15...

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Bibliographic Details
Main Authors: Chao-Yuan Chang, Hao-Jen Hsu, Jossen Foo, Hung-Jen Shih, Chun-Jen Huang
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Pharmaceuticals
Subjects:
TNF-α
necroptosis
pyroptosis
apoptosis
autophagy
mitochondrial injury
Online Access:https://www.mdpi.com/1424-8247/13/10/280

Internet

https://www.mdpi.com/1424-8247/13/10/280

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