Engineered mesenchymal stem cell-derived small extracellular vesicles for diabetic retinopathy therapy through HIF-1α/EZH2/PGC-1α pathway

Engineered mesenchymal stem cell-derived small extracellular vesicles for diabetic retinopathy therapy through HIF-1α/EZH2/PGC-1α pathway

Diabetic retinopathy (DR) is a leading cause of blindness worldwide with limited treatment options. Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) hold promise as a cell-free therapy for retinal diseases. In this study, we present evidence that the intravitreal injection of MS...

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Bibliographic Details
Main Authors: Fengtian Sun, Yuntong Sun, Xiaoling Wang, Junyan Zhu, Shenyuan Chen, Yifan Yu, Mengyao Zhu, Wenrong Xu, Hui Qian
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-03-01
Series:Bioactive Materials
Subjects:
Small extracellular vesicles
Diabetic retinopathy
Mesenchymal stem cell
MiRNA
Engineering
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X23003572

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http://www.sciencedirect.com/science/article/pii/S2452199X23003572

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