Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1α and activating the Wnt/β-catenin signaling pathway

Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1α and activating the Wnt/β-catenin signaling pathway

Abstract Background Osteoporosis is a very common skeletal disorder that increases the risk of fractures. However, the treatment of osteoporosis is challenging. Hypoxia-inducible factor-1α (HIF-1α) plays an important role in bone metabolism. Roxadustat is a novel HIF stabilizer, and its effects on b...

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Bibliographic Details
Main Authors: Luyao Li, Afang Li, Li Zhu, Liangying Gan, Li Zuo
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Roxadustat
Hypoxia-inducible factor
Osteoblast differentiation
Wnt/β-catenin pathway
Bone remodeling
Osteoporosis
Online Access:https://doi.org/10.1186/s13018-022-03162-w

Internet

https://doi.org/10.1186/s13018-022-03162-w

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