Mild catalytic defects of tert rs61748181 polymorphism affect the clinical presentation of chronic obstructive pulmonary disease

Mild catalytic defects of tert rs61748181 polymorphism affect the clinical presentation of chronic obstructive pulmonary disease

Abstract Chronic obstructive pulmonary disease (COPD) is a disorder of accelerated lung aging. Multiple pieces of evidence support that the aging biomarker short telomeres, which can be caused by mutations in telomerase reverse transcriptase (TERT), contribute to COPD pathogenesis. We hypothesized t...

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Bibliographic Details
Main Authors: Jialin Xu, Diego Madureira de Oliveira, Matthew A. Trudeau, Yang Yang, Jessica J. Y. Chin, Don D. Sin, Andrew J. Sandford, Judy M. Y. Wong
Format: Article
Language:English
Published: Nature Portfolio 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83686-z

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https://doi.org/10.1038/s41598-021-83686-z

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