Exploring rigid-backbone protein docking in biologics discovery: a test using the DARPin scaffold

Exploring rigid-backbone protein docking in biologics discovery: a test using the DARPin scaffold

Accurate protein-protein docking remains challenging, especially for artificial biologics not coevolved naturally against their protein targets, like antibodies and other engineered scaffolds. We previously developed ProPOSE, an exhaustive docker with full atomistic details, which delivers cutting-e...

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Bibliographic Details
Main Authors: Francis Gaudreault, Jason Baardsnes, Yuliya Martynova, Aurore Dachon, Hervé Hogues, Christopher R. Corbeil, Enrico O. Purisima, Mélanie Arbour, Traian Sulea
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
binding affinity
protein-protein docking
rigid backbone
DARPin
ProPOSE
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1253689/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1253689/full

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