Exploration of protective strategies against oligodendrocyte cell death in Krabbe disease models
Krabbe disease (KD) patients accumulate psychosine (galactosylsphingosine), a cytotoxic metabolite for oligodendrocytes, inducing early demyelination. Apoptosis has been suggested that plays an important role in psychosine-induced oligodendrocytes cell death in culture and in brains of Krabbe patien...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-02-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/conf.fncel.2015.35.00034/full |