Polymorphism 3435c> t of the ABCB1 gene (rs1045642) does not affect the mirtazapine efficiency and safety profile in patients with depressive disorders comorbid with alcohol use disorder
Background. Mirtazapine is used to treat patients with depressive disorders. A large proportion of patients in this group do not adequately respond to mirtazapine therapy, while many develop undesirable drug reactions of type A. According to the previous studies, P-gp is involved in the biotransform...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Siberian State Medical University (Tomsk)
2021-01-01
|
| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/4152 |
| _version_ | 1797872826715209728 |
|---|---|
| author | M. S. Zastrozhin E. A. Grishina K. A. Ryzhikova V. Yu. Skryabin S. G. Koporov E. A. Bryun D. A. Sychev |
| author_facet | M. S. Zastrozhin E. A. Grishina K. A. Ryzhikova V. Yu. Skryabin S. G. Koporov E. A. Bryun D. A. Sychev |
| author_sort | M. S. Zastrozhin |
| collection | DOAJ |
| description | Background. Mirtazapine is used to treat patients with depressive disorders. A large proportion of patients in this group do not adequately respond to mirtazapine therapy, while many develop undesirable drug reactions of type A. According to the previous studies, P-gp is involved in the biotransformation of mirtazapine, the activity of which is highly dependent on the polymorphism of the gene encoding it.Aim. The aim of our study was to study the effect of mirtazapine gene polymorphism on the efficacy and safety of mirtazapine therapy in patients with depressive disorders, comorbid with alcohol dependence.Materials and methods. The study included 119 male patients with depressive disorders, comorbid with alcohol dependence (age 38.7 ± 16.0 years). As a therapy, mirtazapine was used at a dose of 37.8 ± 13.8 mg / day. Evaluation of the effectiveness profile was carried out using psychometric scales. The safety profile was evaluated using the UKU Side-Effect Rating Scale. Genotyping was carried out by polymerase chain reaction in real time.Results. In the course of the study, results statistically significant in terms of evaluating efficacy and safety were not obtained (HAMD scores at the end of the course of therapy: (CC) 2.5 [2.0; 4.0], (CT) 2.0 [ 1.0; 3.0] and (TT) 2.0 [1.0; 3.0], p > 0.999; according to the UKU scale: (CC) 3.0 [2.8; 3.0], ( CT) 3.0 [3.0; 3.0] and (TT) 3.0 [3.0; 3.0], p > 0.999).Conclusion. The study of 119 patients with depressive disorders comorbid with alcohol dependence showed that 3435C> T polymorphism of the ABCB1 gene (rs1045642) does not affect the clinical efficacy and safety of mirtazapine. |
| first_indexed | 2024-04-10T01:05:14Z |
| format | Article |
| id | doaj.art-5dca72f9a4594efe8a4895f8c5943d7d |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:05:14Z |
| publishDate | 2021-01-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-5dca72f9a4594efe8a4895f8c5943d7d2023-03-13T09:58:26ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842021-01-01194737910.20538/1682-0363-2020-4-73-792724Polymorphism 3435c> t of the ABCB1 gene (rs1045642) does not affect the mirtazapine efficiency and safety profile in patients with depressive disorders comorbid with alcohol use disorderM. S. Zastrozhin0E. A. Grishina1K. A. Ryzhikova2V. Yu. Skryabin3S. G. Koporov4E. A. Bryun5D. A. Sychev6Московский научно-практический центр (МНПЦ) наркологии; Российская медицинская академия непрерывного профессионального образования (РМАНПО)Российская медицинская академия непрерывного профессионального образования (РМАНПО)Российская медицинская академия непрерывного профессионального образования (РМАНПО)Московский научно-практический центр (МНПЦ) наркологииМосковский научно-практический центр (МНПЦ) наркологииМосковский научно-практический центр (МНПЦ) наркологии; Российская медицинская академия непрерывного профессионального образования (РМАНПО)Российская медицинская академия непрерывного профессионального образования (РМАНПО)Background. Mirtazapine is used to treat patients with depressive disorders. A large proportion of patients in this group do not adequately respond to mirtazapine therapy, while many develop undesirable drug reactions of type A. According to the previous studies, P-gp is involved in the biotransformation of mirtazapine, the activity of which is highly dependent on the polymorphism of the gene encoding it.Aim. The aim of our study was to study the effect of mirtazapine gene polymorphism on the efficacy and safety of mirtazapine therapy in patients with depressive disorders, comorbid with alcohol dependence.Materials and methods. The study included 119 male patients with depressive disorders, comorbid with alcohol dependence (age 38.7 ± 16.0 years). As a therapy, mirtazapine was used at a dose of 37.8 ± 13.8 mg / day. Evaluation of the effectiveness profile was carried out using psychometric scales. The safety profile was evaluated using the UKU Side-Effect Rating Scale. Genotyping was carried out by polymerase chain reaction in real time.Results. In the course of the study, results statistically significant in terms of evaluating efficacy and safety were not obtained (HAMD scores at the end of the course of therapy: (CC) 2.5 [2.0; 4.0], (CT) 2.0 [ 1.0; 3.0] and (TT) 2.0 [1.0; 3.0], p > 0.999; according to the UKU scale: (CC) 3.0 [2.8; 3.0], ( CT) 3.0 [3.0; 3.0] and (TT) 3.0 [3.0; 3.0], p > 0.999).Conclusion. The study of 119 patients with depressive disorders comorbid with alcohol dependence showed that 3435C> T polymorphism of the ABCB1 gene (rs1045642) does not affect the clinical efficacy and safety of mirtazapine.https://bulletin.ssmu.ru/jour/article/view/4152миртазапинabcb1фармакогенетикабиотрансформацияперсонализированная медицинадепрессивные расстройстваалкогольная зависимость. |
| spellingShingle | M. S. Zastrozhin E. A. Grishina K. A. Ryzhikova V. Yu. Skryabin S. G. Koporov E. A. Bryun D. A. Sychev Polymorphism 3435c> t of the ABCB1 gene (rs1045642) does not affect the mirtazapine efficiency and safety profile in patients with depressive disorders comorbid with alcohol use disorder Бюллетень сибирской медицины миртазапин abcb1 фармакогенетика биотрансформация персонализированная медицина депрессивные расстройства алкогольная зависимость. |
| title | Polymorphism 3435c> t of the ABCB1 gene (rs1045642) does not affect the mirtazapine efficiency and safety profile in patients with depressive disorders comorbid with alcohol use disorder |
| title_full | Polymorphism 3435c> t of the ABCB1 gene (rs1045642) does not affect the mirtazapine efficiency and safety profile in patients with depressive disorders comorbid with alcohol use disorder |
| title_fullStr | Polymorphism 3435c> t of the ABCB1 gene (rs1045642) does not affect the mirtazapine efficiency and safety profile in patients with depressive disorders comorbid with alcohol use disorder |
| title_full_unstemmed | Polymorphism 3435c> t of the ABCB1 gene (rs1045642) does not affect the mirtazapine efficiency and safety profile in patients with depressive disorders comorbid with alcohol use disorder |
| title_short | Polymorphism 3435c> t of the ABCB1 gene (rs1045642) does not affect the mirtazapine efficiency and safety profile in patients with depressive disorders comorbid with alcohol use disorder |
| title_sort | polymorphism 3435c t of the abcb1 gene rs1045642 does not affect the mirtazapine efficiency and safety profile in patients with depressive disorders comorbid with alcohol use disorder |
| topic | миртазапин abcb1 фармакогенетика биотрансформация персонализированная медицина депрессивные расстройства алкогольная зависимость. |
| url | https://bulletin.ssmu.ru/jour/article/view/4152 |
| work_keys_str_mv | AT mszastrozhin polymorphism3435ctoftheabcb1geners1045642doesnotaffectthemirtazapineefficiencyandsafetyprofileinpatientswithdepressivedisorderscomorbidwithalcoholusedisorder AT eagrishina polymorphism3435ctoftheabcb1geners1045642doesnotaffectthemirtazapineefficiencyandsafetyprofileinpatientswithdepressivedisorderscomorbidwithalcoholusedisorder AT karyzhikova polymorphism3435ctoftheabcb1geners1045642doesnotaffectthemirtazapineefficiencyandsafetyprofileinpatientswithdepressivedisorderscomorbidwithalcoholusedisorder AT vyuskryabin polymorphism3435ctoftheabcb1geners1045642doesnotaffectthemirtazapineefficiencyandsafetyprofileinpatientswithdepressivedisorderscomorbidwithalcoholusedisorder AT sgkoporov polymorphism3435ctoftheabcb1geners1045642doesnotaffectthemirtazapineefficiencyandsafetyprofileinpatientswithdepressivedisorderscomorbidwithalcoholusedisorder AT eabryun polymorphism3435ctoftheabcb1geners1045642doesnotaffectthemirtazapineefficiencyandsafetyprofileinpatientswithdepressivedisorderscomorbidwithalcoholusedisorder AT dasychev polymorphism3435ctoftheabcb1geners1045642doesnotaffectthemirtazapineefficiencyandsafetyprofileinpatientswithdepressivedisorderscomorbidwithalcoholusedisorder |